Sentence examples for mutation and less from inspiring English sources

The evidences supporting the incidence of increased mutation and less efficient negative selection are presented and discussed.

However, HM90822B was unable to halt the growth of tumors formed from cells with an additional T790M (EGFR TKI-resistant) mutation and less expression of EGFR.

The mitochondrial theory of aging is based on the fact that mitochondrial DNA (mtDNA) has a higher rate of mutation and less efficient repair machinery compared to nuclear DNA.

Although Wnt-2 is also expressed in A427 cells, its canonical signaling is probably more dependent on the β-catenin mutation and less dependent on the upstream signaling by Wnt ligands [ 43].

HCC has been classified into two major groups according to chromosomal stability status [ 36]; tumors characterized by chromosomal instability were associated with more p53 mutation and less β-catenin mutation, the two major genetic mutations in human HCC [ 17, 24, 25].

The spectrum of disease-associated mutations includes frequent truncating mutations and less frequent missense mutations.

SHM introduces missense mutations and (less frequently) deletions or insertions into the V regions of Igs.

Cervical adenocarcinoma has recently been shown to contain more frequent TP53 [ 44] and KRAS mutations and less frequent PIK3CA and PTEN mutations compared with squamous cell carcinoma [ 45].

Breast cancer in a woman under age 35 years should prompt one to consider familial breast cancer syndromes and genetic testing for BRCA1/ 2 mutations and, less commonly, TP53 mutations.

Studies in humans have shown that breast cancer with BRCA1 mutations and less commonly BRCA2 mutations display predominantly a triple negative immunophenotype with distinct basal-like subtype [ 31, 32].

The elimination of recombination across a genomic region will, in essence, lower the effective population size of that region, making fixation more likely for slightly deleterious mutations and less likely for slightly beneficial ones.