Sentence examples similar to mutation and led from inspiring English sources

Exon 7 of the MR gene contains 131 bp and this exon skipping creates an out-of-frame mutation and leads to PTC in exon 8 in mRNA.

An overexpression of abnormal GFAP appears as a result of a mutation, and leads to filament disorganization, decreased solubility, possibly ineffective degradation and clearance of the aberrant protein [ 8].

The earlier research has uncovered many mutations and led to the development of a few so-called targeted drugs, which treat some cancers by homing in on specific defects in the cells.

In addition, the T1799A alteration can rather be associated with a second nucleotide mutation (G1798A) and leads to a V600K mutation in an additional ~6% to 29% of patients with a BRAF mutation [ 6].

These findings intensified the analysis of disease-associated mutations in JAKs and led to identification of several mutations in JAK1, JAK2, JAK3 and Tyk2 in different diseases.

This demonstrates that alteration of RUNX1 function may increase the rate of mutation and lead to an accumulation of mutated cells.

A reduction or a loss of editing could generate such a selective pressure for a C-to-T mutation and lead to the elimination of an editing site.

However, when highly expressed, non-fungal squalene synthases could not complement the yeast mutation and instead led to the accumulation of a toxic intermediate(s) as defined by mutations of genes downstream in the ergosterol pathway.

This sequence is exposed when several mutations occur and leads to aggregation of p53.

Together with the reduced homogenizing effect of meiotic recombination between sister chromosomes from different parental lineages, mutations accumulate and lead to divergence in the region of inversion.

This is likely the first of many trials that will go beyond just selecting patients based solely on the presence of a KRAS mutation and hopefully lead to more effective treatments for genetically defined subsets of KRAS mutant NSCLC.