Sentence examples for mutation and further from inspiring English sources

Our haplotype analysis excludes the presence of a common founder mutation and further supports the theory that the c.320C>T position is as a mutational hot spot.

This indicated that LOV1 HA can functionally complement the lov1-4 mutandon and further suggested that the early flowering phenotype seen in lov1-4 mutants resulted from the presence of the Ds transposon and, consequently, from the disruption of the LOV1 gene structure.

Unnecessary antiviral therapy may induce virus mutation and further increases the economic burden.

When the mitochondrial dysfunction persists, it produces genome instability (mtDNA mutation) and further lead to malignant transformation (metastasis) via increased ROS and apoptotic resistance.

These findings support the involvement of the EVC2 mutation in microtia-associated malformations, although formal proofs needs to come from the identification of additional patients with the mutation and further functional validation of the effect of the mutation on the EVC2 protein.

In addition, given that the primary structure of CHEK2 is unaltered by the E84E mutation, and further, that it was observed at a similar frequency in cases and controls suggests against the possibility that this variant may affect an exonic splicing enhancer or aberrantly affect protein translation rates.

The marginal levels of telomerase in the cell, Hockemeyer said, result is some unprotected chromosome ends in the surviving mutant cells, which could cause mutations and further fuel tumor formation.

Sixteen deleterious substitutions were chosen among 54 known missense mutations and further ranked by stability change score into six structural and ten functional mutations with large and small stability changes, respectively.

This indicates that the simple interference with a single aspect of the neuroinflammatory response is not per se sufficient to modify ALS onset and progression induced by SOD1 mutations and further supports the concept that it is the convergence of damage developed within multiple cell types, including neighbouring non-neuronal cells, which is crucial to neuronal dysfunction [39].

We identified several different alleles of mt2 mutations and further analyzed three of them.

Conflicting results are thus apparent regarding differences in these two mutations and further data collection is required.