Sentence examples for mutation and functional from inspiring English sources
Genes with different functions are originally generated from some ancestral genes by gene duplication, mutation and functional recombination.
Genome aberrations in cancer cells can be divided into two types: random 'passenger mutation' and functional 'driver mutation'.
Thorough examination of well-conserved residues in these structures, by point mutation and functional assay with the Xenopus oocyte recording system, strongly suggest that these "loops" include three β-turns and some degree of folding.
Two Myb binding motifs were also identified, and their role in regulating transcription was examined by mutation and functional testing.
Despite infrequent inactivation in many cancers, mutation and functional data have established that KDM6A is a bona fide tumor suppressor gene.
The other group of mutated genes, which affect protein function and involve tumor initiation and/or progression, may be called 'drivers.' Distinguishing the driver genes from the passengers is challenging, but the integration of aUPD analysis with mutation and functional data can overcome this problem.
The impact of individual mutations and functional groupings was assessed by comparing frequencies in cases of MPM versus cases with a single first primary melanoma, and by comparing the reported incidence rates in first-degree relatives.
The information in FragKB can be accessed through a web interface that facilitates sequence and structural visualization of fragments together with known literature information on the consequences of specific residue mutations and functional annotations of proteins and fragment clusters.
These short motifs arise by evolutionary convergence, i.e. by random mutations and functional selection, rather than duplication and subsequent divergent spread in the genome, such as in the case of binding domains [59].
The strength of a correlation between mtDNA mutations and functional impairment of complex I is even more striking in other oncocytomas, e.g. renal and pituitary oncocytic tumors [ 11- 14].
The analysis of the mutations and functional roles of SOX9, ARID1A, ATM and FAM123B suggested they are highly potential colorectal cancer-related genes.
