Sentence examples for mutation and four from inspiring English sources

The tumor with the most mutated genetic landscape contained a shared SETD2 mutation and four nonshared mutations (in genes KDM5C, BAP1, and PBRM1).

Primary skin fibroblasts isolated from four patients homozygous for the I1061T mutation and four control individuals were cultured under identical conditions.

In addition, a cell line derived from a parent of an FD patient, and therefore heterozygous for the FD mutation, and four matched cell lines derived from healthy individuals were used as controls.

We found that a stop mutation and four missense mutations (K103R, C238Y, K241E, and R271W) completely disrupted the PDE4A5 binding.

Retrospective Sanger and 454 sequencing instead revealed a V600K mutation, and four of these 10 patients had a partial response.

To confirm the functional impact of SDHA mutation, we assessed SDHA protein expression by western blotting in seven WT GISTs, including three samples from the two patients with SDHA mutation and four without SDHA mutation.

One of them carries a BHD mutation and eight of them have TP53 mutations (72.7% of TP53-mutated chromophobe; P<0.02).

To further improve the activity, the F124W mutation and three previously reported beneficial mutations were combined randomly into double and triple mutants.

Four individuals with severe POAG were found to have novel missense mutations in exon 3. Two exhibit an Asp380Asn mutation and two an Arg342Lys mutation.

One pathogenic BRCA1 mutation and two novel pathogenic BRCA2 mutations were detected in two of 37 index cases.

Four additional patients carried one missense mutation and one insertion or deletion mutation, and the missense mutations in these four patients were accurately detected.