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However, these impacts of mutation and drift are apparently attenuated by selection on amino acid composition at high-expression genes.
PopG limits itself to a one-locus, 2 allele model, but lets one investigate all the interactions between selection, migration, mutation, and drift (by specifying the population size).
In 1969, Jukes and Jack King put forth their definitive statement of the neutral theory in a paper entitled, "Non-Darwinian Evolution". They argued that the rate of protein evolution in non-essential regions occurred much too quickly to be accounted for by Haldane's cost of selection, and were therefore most likely the result of mutation and drift.
Using gene duplication to explain variational patterns by the action of mutation and drift alone, instead of also invoking selection, is tempting.
Natural selection is the only evolutionary force which can produce adaptation, the fit between organism and environment, or conserve genetic states over very long periods of time in the face of the dispersive forces of mutation and drift.
We ask what level and pattern of sequence diversity should be expected under this scenario, when both epidemiological and genetic equilibrium between mutation and drift are achieved.
Similar(21)
Muir [ 14] showed that accuracy of GEBVs is not only persistent due to historic mutations and drift, but also when LD originates only from recent drift and selection.
Since the microsatellite data rely on putatively neutral markers, part of the genetic differentiation may be explained by mutations and drift.
Part 2: The forces of evolution - selection, mutation, migration, and drift - Populus exercises.
Neutral processes allow explicit predictions to be made, such that a comparison across loci permits inferences about mutation, migration and drift.
We all believe in mutation, selection, and drift, I hope.
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