Sentence examples for mutation and differentiation from inspiring English sources

To establish a causative link between the Tcf3 mutation and differentiation deficiency, a homozygous Tcf3 gene trap clone, P1-2, was transfected with a Cre expression plasmid.

When focusing on the actually observed PFS, we investigated by Cox regression analysis the influence of each miRNA on PFS, using KRAS mutation status, the interaction term between miRNA and KRAS mutation, and differentiation grade as covariates.

Here, we report generation of induced pluripotent stem cells that carry the p.G2019S mutation G2019S-iPSCss) in the Leucine-Rich Repeat Kinase-2 (LRRK2) gene, the most common PD-related mutation, and their differentiation into DA neurons.

The underlying aetiology of acute myeloid leukaemia (AML) remains unknown but is hypothesized to be due a combination of genetic defects giving rise to an acquired proliferative advantage (a Class 1 mutation) and impaired differentiation of a stem cell (a Class 2 mutation).

When comparing the genomes of these so-called genetically monomorphic organisms, we could distinguish differentiation by mutation producing SNVs and differentiation by genome content.

However, these mutations have not been identified in Asian populations (e.g., Japanese and Korean), suggesting the existence of founder mutations and ethnic differentiation.

The p53 protein, encoded by p53 tumor suppressor gene (17p13), is involved in cell-cycle regulation, DNA repair, inhibition of spontaneous mutations, and cellular differentiation and apoptosis [ 8].

However, use of retroviral vectors during iPS cell generation has limited the technique's clinical application due to the potential risks resulting from genome integration of transgenes, including insertional mutations and altered differentiation potentials of the target cells, which may lead to pathologies such as tumorigenesis.

CD24 mRNA overexpression correlates strongly with p53 gene mutation and poor HCC differentiation [ 18].

Furthermore, primary cells cultured from patients with FGFR2 mutations and mice generated with the same mutations show differing proliferation and differentiation characteristics (reviewed in [ 22]).

We assess the functional effects of somatic mutations on SC proliferation and differentiation and predict the global consequence on muscle aging and sarcopenia.