Sentence examples for mutation and consequent from inspiring English sources

Delayed mutation and consequent evolutionary stasis in an animal host are not unreasonable, but in what host?

26 K562 cells carry a monoallelic insertion mutation in exon 5 of p53, resulting in a frameshift mutation and consequent expression of a truncated nonfunctional p53 protein of 148 amino acids.

These are β-catenin-responsive genes (Caldwell et al, 2006): in the absence of epigenetic silencing, APC mutation and consequent β-catenin action would lead to Wnt antagonist induction in a negative feedback loop (Caldwell et al, 2008), starving the tumour cell of Wnt ligand.

After the acquisition of the first D oncogenic mutations, and consequent increase in fitness, an additional C D oncogenic mutations must occur to complete the transformation to a malignant lineage (Figure 1B).

Furthermore, as p53 missense mutations and consequent overexpression (positivity) is infrequent in clear cell carcinomas, but common in high-grade serous carcinoma, positive staining for p53 could be a potential marker to distinguish between these two tumors [ 27].

The proposed scenario for the fate of transferred genes in bacteria based on these observations includes their uptake, duplication, rapid diversification of gene copies by mutations, and consequent fixation of the "best" copies and elimination of other duplicates.

Specifically we have presented evidence to suggest that while WT p53 might primarily function as the "guardian of the genome" (inducing cells to undergo apoptosis or cell cycle arrest under stress), the WT p53 gene sequence is evolutionarily maintained such that it is susceptible to inactivating mutations and consequent cell survival (with the untoward result of tumorigenesis).

Developing a vaccine that will stimulate broad HIV-specific T cell responses is difficult because of the variability in HIV T cell epitope sequences, which is in turn due to the high mutation rate and consequent strain diversity of HIV-1.

This may be due to differences among patients in the severity of the underlying mutation(s) and consequent degree of residual enzyme activity; however, other factors may also contribute to the well-known phenotypic heterogeneity.

Watch out for the occurrence of rpiR mutations and the consequent loss of the ribose requirement.

However, the molecular and cellular mechanisms linking ARS mutations and the consequent pathology remain unclear.