Sentence examples for mutation and at from inspiring English sources

None of the infections consisted solely of wild-type parasites at the dhfr locus: all 191samples had the 108N mutation and at least one additional mutation in c51 (85.9%, 164/191) or c59 (79.6%, 152/191).

For this analysis, we estimated the likelihood of each genotype for individuals who had a p53 mutation and at least one relative who had been genotyped for a MDM2, MDM4, or p53 codon 72 polymorphism.

An extreme example was the highly polymorphic site 28, which was under HLA A*03-mediated selection pressure (corresponding to the H28R mutation) and at which 10 AA states and 29 associations were found, revealing a sub-network of topologically close associations.

After passaging these cultures three times, RNA was extracted and used as template in an RT-PCR reaction spanning the mutation and at least one canonical splice junction.

Therefore, the parents of a proband are obligate heterozygotes for a disease-causing mutation, and at conception each sibling of an affected individual has a 25% chance of being affected and a 50% chance of being an asymptomatic carrier.

Since we observe 5′-extended transcripts adjacent to the tfc6 promoter mutation and at affected Pol III binding sites, it appears that alteration of TSSs may be a general result of altered protein-DNA binding within chromatin.

Counsyl is doing genetic tests that look for more than 400 mutations and at least 100 genetic disorders for parents who are planning children.

Overall, the in vitro system generates expansions that mirror disease-initiating mutations and at frequencies in line with expectations.

In total, we observed 4/121 F1 animals with mutations and at least one case of biallelic heritable mutations in the dpy-3 targeting experiment.

Because I carry the BRCA2 genetic mutation and was at a statistically higher risk for ovarian cancer, I chose to to have prophylactic surgery to remove my ovaries and fallopian tubes.

This high mutation rate leads to recurrent mutation, back mutation, and multiallelism at microsatellite loci (Ellegren 2004).