Sentence examples for mutation and amplification from inspiring English sources

In routine cancer molecular pathology, various independent experiments are required to determine mutation and amplification status of clinically relevant genes.

Based on studies with imatinib, mutation and amplification of the target kinase seem to be the most important mechanisms for the development of resistance, but these mechanisms alone cannot explain all cases of resistance.

Genomic instability is the increased rate of acquisition of alterations in the mammalian genome, and includes such diverse biological endpoints as chromosomal destabilization, aneuploidy, micronucleus formation, sister chromatid exchange, gene mutation and amplification, variations in colony size, reduced plating efficiency, and cellular transformation.

This is based on the result of studies showing that, while uncommon in hormonally naïve patients, AR gene mutation and amplification, resulting in elevated AR protein expression, are detected in the majority of metastatic prostate cancer tissues obtained from patients with castrate-resistant metastatic disease [12], [13].

KO and HS carried out mutation and amplification assays.

Mutation and amplification are probably both important in determining TKI sensitivity.

EGFR mutations and amplification represent the gene's main deregulation mechanisms in cancers of different histo-genetic origin.

Mutations and amplification of EGFR are common in non-small-cell lung carcinoma and provide the basis for treatment with EGFR-inhibitors.

PIK3CA mutations and amplification were found in FTC.

PIK3CA mutations and amplification were found in 8/113 (7.1%) and 88/131 (67%) gastric cancer patients, respectively.

PIK3CA mutations and amplification are two major causes of overactivation of this pathway in human cancers.