Sentence examples for mutation and activated from inspiring English sources

This observation indicated that PAK1 expression is modulated by APCmin mutation and activated β-catenin signaling in the polyps.

And, HepG2 cell line was reported to have mutation and activated β-catenin (de La Coste et al, 1998).

These preclinical studies suggested that MEK inhibitors or CRAF inhibitors may benefit patients with concomitant kinase-silent BRAF mutation and activating RAS mutation.

In contrast to the absence of concomitant BRAF p.V600E mutation and activating RAS mutation, 3 of 7 (43 %) NSCLCs and 3 of 27 (11 %) CRCs with a p.V600E (c.1799 T > A) showed a concomitant mutation in the AKT or PIK3CA genes of the mTOR pathway.

No relationship between the presence of KRAS, or BRAF mutations and activated Src or FAK was appreciated.

Our work suggests that both kinase-active and kinase-impaired CFC alleles are effectively gain-of-function mutations and activate the pathway because combinations of active and impaired BRAF mutant alleles can promote an additive effect during early development (Fig.  4).

Tumours with truncating APC mutations and activating K-ras mutations in codons 12 and 13 occurred at similar frequencies (37% (245/656) and 36% (235/656), respectively).

Truncating APC mutations alone and activating K-ras mutations in codons 12 and 13 only, occurred at similar frequencies (20% (130/656) and 18% (121/656), respectively).

When the gene for microRNA-203 was added into skin cells carrying the Hras mutation and then activated, the cells both divided less and, as a results, grew less.

In this study, we established that the NS1 A374G substitution induced a D125G coding mutation and concomitantly activated a novel donor splice site, hence producing the novel viral transcript and protein, NS3.

Inactivating mutation of PTEN and activating mutation of PIK3CA have been detected in many human cancers and have been known as major activating mechanisms of AKT-signalling pathway in cancers (Testa and Bellacosa, 2001; Samuels et al, 2004).