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Heterozygous APPPS1 mice coexpress a human APP with the Swedish mutation and a mutated PS1 (L166P) under the neuron-specific Thy1-promoter [ 23].
Only one tumour was mutated: this tumour had no KRAS mutation and a pMMR phenotype.
"In humans, you can get a single point mutation, and a vaccine that's 99.99percentt related won't protect you".
Li et al. propose a modified DE which consists of a best random mutation and a randomized local search [22].
A 1-bp deletion in OsGLP8-1 caused a frameshift mutation, and a nucleotide substitution in OsGLP8-11 resulted in a premature stop codon.
A new mutation and a new crossover operator were defined to complement the standard crossover and mutation operators of the basic Holland's GA.
The initial weight objects are then obtained by a global search using selection, crossover, mutation, and a two-way communication rule.
Ms. Jolie Pitt opted to have a prophylactic bilateral mastectomy after testing positive for the BRCA gene mutation, and a laparoscopic bilateral salpingo-oophorectomy upon a screening that yielded early signs of cancer.
The sequence of the K103N-positive amplicon contained the K219Q mutation and a T215F/V mixture.
The 3' homologous region introduced the FDD mutation and a BamHI site into the BRI2 mouse gene.
We introduced a Lys22 to Ala (cdk4K22A) mutation and a triple mutation His281, Lys282, Arg283 to Ala (cdk4H281-3A).
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