Sentence examples for mutation analysis on from inspiring English sources

Since vast majority of PIK3CA gene mutations in human cancers were reported in exons 9 and 20, we focused our mutation analysis on these exons (Samuels et al., 2004).

Future studies on the full-length structures of class-C GPCRs, as well as more detailed mutation analysis on the linker-ECL2 interaction will be necessary to verify the current hypothesis on the mechanisms for the activation of class-C GPCRs and in particular the mechanisms for signal transduction from the ECD dimer to the 7-TM dimer.

We then we performed a second independent mutation analysis on all samples and observed that the results of the BRAF/KRAS and PIK3CA/NRAS assays were completely reproducible.

Genes were selected for mutation analysis on the basis of likely high mutation frequency (based on cMS length), likely immunogenicity (based on mutant C-terminus amino acid length) and likely expression in colon cancer (based on gene and protein expression data where available).

The sibling was found to carry E146K and subsequent point mutation analysis on case 7s neonatal screening card was positive.

However, in a clinical setting there are several challenges when performing mutation analysis on DNA from routinely formalin-fixed, paraffin-embedded (FFPE) tissue samples.

The microarray detection limit was assessed based on the mutation analysis of two plasmids carrying exon 1 of the gene coding for low-density lipoprotein receptor with two types of mutations (i.e. G>T, G>A).

In contrast to this approach, which focused on mutation analysis for a specific, previously known resistance marker [ 55], genome-wide analysis strategies should, in theory, capture all possible mechanisms of resistance.

Successful EGFR mutation analysis performed on the single laser capture micro-dissected (LCM) lung cancer CTC enriched from patients has been recently published [58].

Correlated mutation analysis based on large sets of diverse sequence data may provide new insights into this question.

Finally, mutation analysis performed on cohorts of individuals with nonsyndromic pulmonic stenosis, atrial septal defects, and ventricular septal defects excluded a major contribution of germline SOS1 lesions to the isolated occurrence of these cardiac anomalies.