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Bioinformatics analysis indicated that the mutation altered the hydrophobicity and secondary structure of the protein.
The L244A mutation altered the stereoselectivity of 2-ethylhexanoic acid production.
This study was performed to determine whether this mutation altered the effectiveness of the adjacent splice site.
Docking calculations showed that the mutation altered the orientation of indole, and that the C-2 of the indole pyrrole ring was closer to the heme iron of P450 BM-3 than the C-3.
The S228P mutation altered the distribution of charged residues and the representative areas are indicated by dotted circles.
A close inspection of the surface electrostatic potentials indicated that the S228P mutation altered the distribution of charged/polar residues around the subunit interface (Fig. 5C).
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Hughes, A. E. et al. Mutation altering the miR-184 seed region causes familial keratoconus with cataract.
Bargmann, C.I., Hung, M.C. & Weinberg, R.A. Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.
These mutations altered the amount of helical content.
Then, the investigators searched through a second set of 66 medulloblastomas, including some samples from adults, to find how these mutations altered the proteins made by the genes.
Thus, the levQE170A/F292S mutations altered the specificity of the signaling complex independently of LevT.
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