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The processes whereby one ancestral gene could have given rise to such a family of genes include gene duplication, crossing over, and mutation, all of which are discussed in detail in genetics.
The 5F8 sequence had four types of mutation, all of which resulted in frameshift mutations and followed stop codons (Fig. 5E and 5F).
Of these 110 samples, 23 carried the G202 mutation, all of which also carried the G376A mutation.
During the acquisition of the katG isoniazid resistance causing mutation all of these heterogeneous variants were lost from the population.
In cases where clonality could be determined by mitochondrial mutation, all of the results were consistent with the clonality decided by methylation status.
In V210I mutation all of the patients presented with a positive MRI scan for CJD (sCJD 83%), we also found WML (30%), but less frequently than in the E200K mutation.
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But because many thousands of genes are involved in brain development, natural selection can't keep them all free of mutations all the time.
Of the five individuals, four were found to have somatic EPAS1 mutations, all of which resulted in mutation of either amino acid residue A530 or P531 (P531R (x2), P531R, A530P 45.
In Fouchier's study it took only five mutations – all of which have been seen in the wild – for bird flu to become airborne and spread through ferrets.
In narrowing the focus, Assimes homed in on three mutations, all of which disrupted normal genetic function.
Other Hispanic and non-Hispanic families harbor different mutations, all of which appear to be null alleles.
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