Over half a century ago, scientists realized that's because the sickle cell mutation affects only the "adult" version of hemoglobin.
In rice, initiation of crown roots is normal in the Lrt1 mutant [6, 31], suggesting that the dominant Lrt1 mutation affects only lateral root development and that lateral and crown root formation can be genetically resolved.
Interestingly, the H479Q mutation affects only slightly the copper-dependent pNPPase activity, while it inhibits strongly the ATPase activity.
Unlike the Mmp9 –/– and Mmp13 –/ mutations, which affected both cartilage and bone tissues during fracture repair, the Mmp2 –/– mutation affected only the bone compartment of the fracture callus.
The necessary threshold level of RUNX1 expression is likely to be cell-specific, explaining why RUNX1 heterozygous mutation affects only hematopoietic cells; nevertheless, our observations could conceivably suggest possible involvement of RUNX1 in solid-tissue tumor.
Our analyses also revealed a significant interaction effect of genotype and day on the use of directed search strategies (F4,36 = 4.92, P = 0.014), indicating that the mutation affects only specific aspects of water maze acquisition.
This partitioned phylogeny results in part from group specific mutations affecting only the cationic region.
Moreover, the observation that the combination of mutations in these two genes dampens the variance caused by mutations affecting only a single gene is intriguing and suggests interacting pathways.
However, to avoid the possibility of confounding phenotypes, we used only the alleles l(3)70Da s4868 and l(3)70Da, which harbor smaller mutations affecting only the 5′ region of the Pex1 gene, for subsequent developmental characterizations.
Initially, recessive mutations in the parkin gene were related to sporadic early onset parkinsonism [ 2]; however, the mode of transmission was subsequently rejected by other genetic studies with not only homozygous or compound heterozygous mutations, but also single heterozygous mutations, affecting only one allele of the gene [ 2, 57– 61].
