Sentence examples for mutation affected both from inspiring English sources

The mutation affected both tau microtubule assembly and tau mRNA splicing with an increase in 4R tau.

The K270M mutation affected both NADPH and NADH affinity in xylose reduction, in contrast to the glyceraldehyde reduction where the apparent affinity for NADH remained unchanged [ 47].

We examined this issue computationally and found that starting with a large population of spores and selecting large pools of segregants (2 × 10) was essential for achieving high mapping power when a mutation affected both the phenotype of interest and relative fitness.

It could be that the L302P mutation also affects this orientation - the mutation affects both polymerization and GTP hydrolysis activity.

Molecular studies demonstrated that the K298E mutation affects both protein function and alternative mRNA splicing.

The Trp107fAla mutation affects both kcat 1500-foldd decreand) and Km (50-fold increase).

In this case, a potential deleterious mutation affecting both populations would be selected against in both groups.

Indeed, direct sequencing detected only one (previously reported) missense mutation affecting both the p14ARF and p16/ CDKN2A genes [ 14].

The evolution of overlapping coding regions is particularly constrained because they simultaneously code for two different genes and any mutation affects both of them (Krakauer 2000).

However, such models do not fit our scenario, because they are designed for overlapping reading frames, where a mutation affects both translated sequences, while in our case the sequences become at one point independent and undergo mutations independently.

With the same gene mutation affecting both the cn/cn mouse and human short stature skeletal dysplasia patients with AMDM, the changes in the mouse begin to demonstrate how molecular abnormalities in the C-type natriuretic peptide gene translate to structural abnormalities.