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In addition, the IBS landscape offers a genomic view of the mutation across the samples.
We also show how IBS can be used to reveal the diversity and occurrence of mutation across the samples.
As there is uneven distribution of mutation across the genome, with lower prevalence observed in gene regions [7], the level of similarity observed in NGS may be an under estimation of mutations in the samples.
As expected, EMS created a random spectrum of mutation across the whole genome of our mutants and biased to G/C-to-A/T changes.
Our results implicate a geographical frequency gradient of the G84E mutation across the European continent, with the mutation being more common in Nordic countries, notably Finland.
It is well established that there is significant variation in the rate of mutation across the genome (e.g., [ 30]), providing a basis for variation in diversity level.
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Supek, F. & Lehner, B. Differential DNA mismatch repair underlies mutation rate variation across the human genome.
Over the past 15 years only a minority of the published studies which have attempted to correlate mutational and IQ data have reported mutations across the full mutation spectrum seen in the DMD gene [1], [26], [32] [36].
Our previous analyses showed a transcriptional strand bias for all C G > A T mutations across the 21 breast cancer mutational catalogs (Nik-Zainal et al., 2012a).
Mutational mapping also records the timings of mutations across the tree, which we have used in calculating evolutionary rates, whereas existing maximum likelihood methods do not.
The CCLE data set also allowed us to analyze the distribution of mutations across the four different Notch receptor genes, to learn whether there are mutational hotspots or whether a particular type of mutation associates with a particular receptor.
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