Sentence examples for mutation achieved a from inspiring English sources

At 24 weeks, 14/25 patients (56%) with baseline JAK2V617F mutation achieved a spleen response.

Forty-four percent of CML patients with the BCR-ABL T315I mutation achieved a response, and responses were reported as durable.

In that study using tumour response according to Miller Payne criteria as a surrogate end point for outcome, 2/2 TNBC patients with a BRCA1 mutation achieved a pathological complete remission (pCR) on conventionally dosed cisplatin [ 37].

Patients with PIK3CA mutations achieved a median PFS of 2.3 month and a median OS of 5.8 months compared to 4.6 and 9.2 months, respectively, in patients who did not carry these mutations.

Finally, a third patient (pt 21) with a KRAS mutation achieved long-lasting stable disease (8 months), under cetuximab-irinotecan treatment.

By this analysis, mutation profiling achieved a similarly high specificity of 99.8%.

Although CHEK2 H371Y carriers were more likely to respond to neoadjuvant chemotherapy, only small subset of mutation carriers achieved a pCR, the majority of CHEK2 H371Y carriers who did not reach a pCR might have a particularly aggressive phenotype.

Four patients (three imatinib resistant, two of whom carried the known imatinib-resistance mutation, M351T) achieved a major cytogenetic response, which corresponded with 1- or 2-log reductions in BCR-ABL transcript levels, and an overall 32% median reduction in BCR-ABL transcripts after 4 weeks of treatment.

All other patients with biopsies performed 2 to 17 months prior to treatment had additional alterations of known significance, except for one individual (case #1) who had only a BRAF mutation and achieved a CR that is ongoing at 28.7+ months.

In a phase I trial of single agent MK4827 enriched with patients having BRCA1 or BRCA2 mutations, 6 patients, including 5 with BRCA mutation, achieved PR.

Another finding in this study which is noteworthy, is 1 patient who had BRAF mutation achieved PR.