Sentence examples for mutation achieved from inspiring English sources

At 24 weeks, 14/25 patients (56%) with baseline JAK2V617F mutation achieved a spleen response.

Another finding in this study which is noteworthy, is 1 patient who had BRAF mutation achieved PR.

Finally, a third patient (pt 21) with a KRAS mutation achieved long-lasting stable disease (8 months), under cetuximab-irinotecan treatment.

Forty-four percent of CML patients with the BCR-ABL T315I mutation achieved a response, and responses were reported as durable.

In a phase I trial of single agent MK4827 enriched with patients having BRCA1 or BRCA2 mutations, 6 patients, including 5 with BRCA mutation, achieved PR.

In that study using tumour response according to Miller Payne criteria as a surrogate end point for outcome, 2/2 TNBC patients with a BRCA1 mutation achieved a pathological complete remission (pCR) on conventionally dosed cisplatin [ 37].

Supporting this idea, mutations achieved in one single T3E rarely affect the virulence phenotype of strains.

Indeed, high-coverage whole-genome sequencing of another population founded from the same strain found that only three synonymous mutations achieved detectable frequencies in 20,000 generations [ 48].

Patients with PIK3CA mutations achieved a median PFS of 2.3 month and a median OS of 5.8 months compared to 4.6 and 9.2 months, respectively, in patients who did not carry these mutations.

In two patients, there were concomitant mutations of KRAS codon 146 and PIK3CA exon 9 and NRAS codon 61and PIK3CA exon 9. Patients with genomic mutations achieved no response to anti-EGFR antibodies (SD: N=6, PD: N=12).

Prophylactic immunisation with 27mer peptides encoding these mutations achieved complete tumour protection and survival in 40% of the mice, whereas all mice in the control group died within 44 days.