Sentence examples for mutation accumulation thus from inspiring English sources

Asking what cell cycle profile minimizes mutation accumulation thus requires minimizing a stochastic objective function, and deriving a range of parameters that perform reasonably well around that minimum.

The performance of cell cycle control strategies in terms of replication-dependent mutation accumulation can thus be assayed by the balance in the cell pedigree trees that they produce.

A longevity gene may enhance the protection against oxygen radicals and thus reduce the danger of bad mutations on which mutation accumulation is based; thus all three theories work together.

In addition, cells which accumulate mutations are prone to apoptosis: Thus, mutation accumulation during the life of an organism may be underestimated.

In addition, theory suggests that effective outcrossing rates of less than 1% do not drastically reduce the rate of mutation accumulation [ 11, 29], thus limiting the potential for transient instances of elevated outcrossing to impact population persistence.

Thus, the mutation accumulation that occurred during each serial transfer can cause structural changes in the individuals, which in turn can further cause a decrease in the mean fitness of the population via Muller's Ratchet and random drift.

The strategy that minimizes pedigree depth and thus replication-dependent mutation accumulation has significant drawbacks.

Is it possible that the yeast TLSPs are also involved in the repair of meiotic DSBs, thus leading to mutation accumulation and adding a new source of genetic variation?

We also found no significant difference in ΔDE between transitions and transversions in the mutation accumulation study (t = 0.271, P = 0.782), thus contrasting the effect observed in the yeast genome (fig. 2 A ).

For example, pleiotropy can maintain functions in environments where they are not under selection and would thus be subject to destruction by mutation accumulation [ 19, 49].

In a mutation accumulation assay, the population is propagated through recurrent single-cell bottlenecks, thus mitigating the effect of selection and allowing mutations (other than lethal mutations) to accumulate as if they were neutral.