Sentence examples for mutation accumulation during from inspiring English sources

In addition, cells which accumulate mutations are prone to apoptosis: Thus, mutation accumulation during the life of an organism may be underestimated.

Third, the observed inbreeding depression could be the resulting equilibrium between purging in the haploid males and a high deleterious mutation accumulation during the asexual generations.

This was probably due to the use of EMS to generate these mutations coupled with spontaneous mutation accumulation during subsequent outgrowth and strain manipulation.

The 100-fold higher mutation rate of mtDNA than nuclear DNA is caused by a combination of oxidative microenvironment, lack of histones, and rudimentary repair mechanisms, leading to mtDNA mutation accumulation during aging.

Given some evidence that checkpoint function may decline with age (Feng et al., 2007) and that older HSC reveal slower in vitro DNA damage repair (Rübe et al., 2011) it is possible to assume a progressive increase of mutation accumulation during ageing.

Potential sources of error in estimating the rate of mutational decline in fitness for a population include confounding factors that bias the rate of mutation-accumulation during MA and factors that bias the measured impact of mutation during fitness assays.

Both CMV and satRNAs were derived from infectious RNA transcripts of full-length cDNA clones (Rizzo and Palukaitis 1990; Escriu et al. 2000a) to minimize mutation accumulation and selection during experimentation in different host plants.

This study advances understanding of yeast tolerance mechanisms to inhibitory substrates and biocatalyst design for a biomass-to-biofuel/biochemical industry, while providing insights into the process of mutation accumulation that occurs during genome shuffling.

Thus, the mutation accumulation that occurred during each serial transfer can cause structural changes in the individuals, which in turn can further cause a decrease in the mean fitness of the population via Muller's Ratchet and random drift.

Each putative mutant was subsequently re-amplified and re-genotyped 2 6 times to distinguish real mutations (acquired during mutation accumulation) from those due to PCR error.

Previous studies in Arabidopsis thaliana (Shaw et al. 2000), Escherichia coli (Perfeito et al. 2007; Trindade et al. 2010), Streptococcus pneumoniae (Stevens and Sebert 2011), and S. cerevisiae (Joseph and Hall 2004; Dickinson 2008) have also found evidence that beneficial mutations are fixed during mutation accumulation experiments.