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Thus, the first process, in which natural selection favors the use of cheaper designs, will usually dominate the second process, in which mutation accumulation decays performance.
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This is in agreement with the finding that the mechanism of antagonistic pleiotropy (consisting on mutations that were detrimental in the previous environment and are beneficial in the new one) appears to be more important than the neutral process of mutation accumulation for the decay of unused catabolic functions [ 25].
After ∼644 generations of mutation accumulation, MA lines had accumulated an average of 118 mutations, and we found that average fitness across all lines decayed linearly over time.
However, our findings do indicate that compensatory mutations can play a major role in producing antagonistic epistasis and thus slowing the decay in mean fitness under random mutation accumulation.
While we have no such information for other correlates such as longevity, number of broods per life, offspring survival, etc., our current limited evidence suggests that P. formosa experiences only little or no genomic decay despite our predictions of substantial deleterious mutation accumulation.
Between-line variability in the rate of mutation accumulation.
Blokzijl, F. et al. Tissue-specific mutation accumulation in human adult stem cells during life.
Albin, R. L. Antagonistic pleiotropy, mutation accumulation, and human genetic disease.
These cells are maintained throughout life, increasing the opportunities for mutation accumulation.
BRCA1 is therefore not a good candidate for mutation accumulation.
Niches modify mutation accumulation.
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