I then mutated one individual with one mutation, mutated a second individual with the second mutation, and mutated the third individual with both mutations, creating both single mutants and a double mutant.
If the patient's results show an inherited mutation, a second visit is typically scheduled to discuss screening and management options as well as risk to other family members.
In all sheep exhibiting the c.2746delCA mutation, a second intronic c.2749+51A>G mutation could be shown.
Given one OMIDI mutation, a second random mutation 3' to the first (either IMIDI or OMIDI) will restore reading frame only 1/3 of the time, and a sub-fraction of that third is still protein truncating because a nonsense mutation occurs prior to the second mutation.
Compensatory mutation: A second-site mutation that occurs after a mutation that confers resistance, which lessens or alleviates the fitness costs associated with resistance.
When they then evaluated which mutations were shared in a single cell, they identified one population with only an ATM mutation, a second with ATM and FSIP2 and a third with ATM, CLTC and GLMN mutations.
Besides these common mutations, a third lamivudine resistant, rare mutation [ 11, 31], namely V519L, was detected in one clone derived from the sample collected in 1999 as well as in all HBV sequences derived from the sample collected in 2002.
Heterozygous carriers of the 985A>G mutation without a second mutation (cases 20, 22 and 23) had residual MCAD activities of 24% or higher (Table 1).
This phenotype is completely suppressed by mutation in a third gene, mec-6 (refs 3, 4), that is needed for touch sensitivity.
Dioecy may have evolved from hermaphrodite or monoecious ancestors by two independent mutations: a first mutation causes male sterility, whereas a second mutation results in decreased female fertility, leading to functional dioecy [ 23].
