Sentence examples for mutating the three from inspiring English sources

The vector miR-181c/d P1m (CDP1m) was generated from CDP1 by mutating the three Egr-1 binding sites to "ATCATAATC".

We found that mutating the three OCT-binding sites of the A2 region weakly affects the enhancer-blocking and CTCF-binding activities of IC1.

In addition, we tested the effect of mutating the three nst genes that we had found resulted in hyperacetylation of histones H3 and H4.

Firstly, mutating the three N-terminal AMOT p130 PPXY motifs strongly inhibited co-immunoprecipitation of HA-AMOT p130 with OSF-NEDD4L.

Work to investigate whether mutating the three putative SUMO conjugation sites may lead to differential subcellular location of PfSir2, or alter var gene de-repression and telomere length, is underway.

This interaction was abolished by mutating the three PPxY motifs in Ncoa6 (Ncor63m) or the two WW domains in Yki (YkiWM), suggesting that the Ncoa6 Yki interaction was mediated by Ncoa6's PPxY motifs and Yki's WW domains.

TetraCys motifs flanking existing extracellular Pro-Gly residues were engineered into EL2, EL3 or EL4 DAT extracellular loops by mutating the two residues upstream and downstream of the Pro-Gly residues into cysteines.

What was the rationale for mutating the two selected Ser residues?

Mutating the two remaining Ser/Thr was then necessary to eliminate β-arrestin2 binding and internalization.

When S188/S190 phosphorylation is prevented by mutating the two residues into alanine, several functional consequences can be observed.

The effect of mutating the two phosphorylated serines in Osk is also apparent when the transgenes are expressed in the presence of wild-type osk.