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Each individual in the population either remains unchanged or mutates to a new feasible solution in one iteration of evolution.
Each day, there is a chance μ = 10-4 than an infection mutates to a new phenotype.
Throughout this article, we assume a neutral infinite-alleles model; i.e. whenever an allele mutates, it mutates to a new allele that has never been seen before.
If we define µ as the substitution rate per site, so a P allele mutates in an S allele at a rate cµ; conversely, an S allele mutates to a P allele at a rate dµ.
This means that, for all NNY-translating tRNAs except for tRNAPhe, even if their regular wobble G mutates to A, the resulting wobble A will NOT be converted to inosine.
Later, the substituted ALA residues were converted back to the original GLY, keeping the Cβ coordinate of ALA to use when a GLY mutates to a residue with Cβ.
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A total of 14 had a mutation where the arginine was mutated to a histidine (c.845G>A, Arg282His); in the remaining 7, the arginine was mutated to cysteine (c.844C>T, Arg282Cys).
In the set of the evolutionarily conserved mutations, we isolated the P1 mutant, in which a conserved tyrosine residue is mutated to a histidine residue.
But in nine months it mutated to a highly virulent one.
Therefore, a CG base pair will have mutated to a TA base pair.
On protecting America against terrorists, their nine-point advantage has mutated to a seven-point deficit.
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