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For example, there are inherited diseases in which the maternal (expressed) copy of a gene is mutated while the paternal copy is wild type but silent.
The resistant HT29 is p53 and K-ras mutated, while the A549 with wild-type p53 is more sensitive.
Each S. cerevisiae histone is present in two copies encoding the same protein, and only one of the two H4 genes (HHF1 to Cys47) and was mutated while the other (HHF2) was replaced with a selectable marker (URA3).
Intriguingly, Analysis of the cervical cancer patient sample from the TCGA datasets indicated that upstream genes involved in the Hippo tumor-suppressing pathway are frequently deleted and mutated, while the effectors, YAP and WWTR1 (TAZ) genes, are frequently amplified in 191 cervical cancer cases (Fig EV1A).
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In R. etli, symbiotic nitrogen fixation was drastically reduced when the rpoN2 gene was mutated, while mutation of the rpoN1 gene did not affect nitrogen fixation levels [ 10].
Furthermore, we used site-directed mutagenesis to create a variant of the LDLRAP1 construct in which the MIR168a target site was mutated while leaving the LDLRAP1 amino-acid sequence intact (Figure 3I).
The rest are studio outtakes that offer a compelling insight into his modus operandi and how the songs mutated while being recorded.
The researchers documented that there was negligible expression when the consensus bases at positions −3 and +4 were mutated, while in case of mutation only at position −3, there was a seven fold reduction in the expression levels.
Years passed, technologies advanced, and genres mutated: while Avril Lavigne's "Complicated" was flooding the airwaves, Electronic Arts and other video game production companies increasingly turned their attention toward drum 'n' bass and hip hop.
D'Andrea thinks Fanconi may arise when both copies of any of the eight Fanconi or BRCA genes are mutated, while one damaged copy can make people vulnerable to breast and other cancers.
These arteries are not mutated, while tumoral cells are, but may be altered by factors released in the microenvironment of the tumor [ 64].
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