Sentence examples for mutated variant of from inspiring English sources

In contrast, a construct expressing a mutated variant of p300, with a mutation affecting the Histone Acetyl-Transferase domain (LY-RR) (36), failed to stabilize endogenous ΔNp63 α in HaCaT cells (Fig.  2B).

A mutated variant of the ENO1 cDNA was constructed by introducing two mutations in the ENO1 sequence, eliminating the alternative translation start codons of MBP-1 (Fig. 1A).

In the current study, haploid Saccharomyces cerevisiae strains expressing a heterologous xylose pathway including either the native xylose reductase (XR) from P. stipiti s, a mutated variant of XR (mXR) with altered co-factor preference, a glucose/xylose facilitator (Gxf1) from Candida intermedia or both mXR and Gxf1 were assessed in SSCF of acid-pretreated non-detoxified wheat straw.

Generally, consequences of short-term inactivation of an essential protein can be investigated by a mutated variant of this protein, which carries out its function at permissive conditions whereas it is blocked at non-permissive conditions.

14 Preliminary investigations have found associations between SAD and a mutated variant of the melanopsin gene, but reproduction of this finding is warranted.

We recently defined a mutated variant of the immunodominant domain of Phl p 1, a major grass pollen allergen, with substantially reduced ability to bind Phl p 1-specific IgE [ 9].

Hence, dissociation experiments have been performed with a set of molecular matched pairs of tiotropium on a large variety of mutated variants of hM3R.

The cells R- cells were stably transfected with human wild type IGF-1R or mutated variants of human IGF-1R (Y950F, Δ1245, Y950F-Δ1245 and Y1136).

The binding site of htt in gp78 was mapped by incubating cell lysates prepared from Nhtt17Q-expressing cells with GST-fusion proteins containing different portions as well as mutated variants of gp78.

The mutated variants of ANTR1 were thereafter expressed and functionally characterized in E. coli.

The mutated variants of the candidate genes are introduced into wildtype S. cerevisiae for identification and validation.