Sentence examples for mutated type of from inspiring English sources

We show that BCCs are the most mutated type of human cancer.

We suggest that the p53 overexpression may be related to the mutated type of this protein.

The precise mechanism(s) for favouring the mutated type of P53 mRNA – however, still remains to be discovered.

In the present study, a human anti-mutant p53 antibody (Abcam™, ab32049), which does not recognize human wild-type p53 protein but does react with a synthetic peptide corresponding to human mutant p53 aa 1-100 (N terminal), was used to detect the mutated type of p53 in the pretreatment biopsy specimens of patients with OSCC.

Although immunohistochemistry does not distinguish between wild-type and mutated or inactivated forms of P53, it is generally accepted that accumulated P53 represents a mutated type (Hall and Lane, 1994).

Currently, IPI is available as a first- or second-line monotherapy for unresectable or metastatic melanoma and is effective for either the wild-type or the B-RAF-V600E-mutated type at a dose of 3 mg/kg of body weight [8].

We can only speculate that given the molecular background of the aCGH classifier (derived from BRCA1-mutated tumours) the type of agents is mandatory, all causing DSBs in the DNA, and explains the beneficial effect of HD-PB chemotherapy.

In our series, dabrafenib showed a remarkable inhibition of cell proliferation in both melanoma cell lines carrying a mutated BRAF (regardless of the type of mutation, BRAFV600D or BRAFV600R), with lack of significant antiproliferative effects in control cells presenting a wild-type BRAF.

The IF takes account of mutational patterns, i.e., we allow the score of a mutated gene g* in the list to depend on the number and type of mutated genes (i.e., mutual exclusivity, topology distance) in its functional neighborhood, as explained in Methods.

This group illustrates that the high level of GEF activity found is not linked to the type of mutated gene nor to a specific degree of clinical severity.

None of these risk factors was a stronger predictor for survival than the type of mutated histone H3 which remained as such in multivariate analysis (p value <0.0001).