A total of 14 had a mutation where the arginine was mutated to a histidine (c.845G>A, Arg282His); in the remaining 7, the arginine was mutated to cysteine (c.844C>T, Arg282Cys).
However, the Ugt1a5b has been mutated to a pseudogene in rhesus monkey because its sequences have a single-nt insertion in the coding region (Fig. 1C).
In the set of the evolutionarily conserved mutations, we isolated the P1 mutant, in which a conserved tyrosine residue is mutated to a histidine residue.
But in nine months it mutated to a highly virulent one.
Therefore, a CG base pair will have mutated to a TA base pair.
On protecting America against terrorists, their nine-point advantage has mutated to a seven-point deficit.
Initially it caused only mild disease that escaped detection, but by 1997 the virus had mutated to a deadly form that could kill chickens within 48 hours.
In addition, Y527 (a conserved residue in α6-7, Fig. S1) was mutated to a variety of amino acid residues.
In EGFR, the crucial Thr790 gatekeeper residue is mutated to a Met and prevents reversible ATP competitive inhibitors from binding.
But the worst scenario--that the virus has mutated to a more dangerous form that could trigger a pandemic--cannot be definitively ruled out until the WHO collaborating center in Atlanta analyses the new samples from Thailand later this week.
European public health officials are investigating a handful of swine flu infections in Norway and Wales in which the virus mutated to a form that's more severe or less sensitive to drug treatment.
