Sentence examples for mutated there was from inspiring English sources

When any of the three sites in the cluster were mutated there was a significant drop in reporter gene activity, the most prominent effect was noted for the Fk3 site (Fig. 5A, B).

When residues near F8 were singly mutated, there was less effect on telomere length than when they were mutated together as groups of six residues.

When the putative miR-183 binding site was mutated, there was no significant decrease in relative luciferase activity compared with control RNA (Fig. 2B).

When Ser and Ser were mutated, there was still a residual 14-3-3-binding 14-3-3-binding 14-3-3-binding 14-3-3-bindingting signalhr and Ser inthatlanine residues.

Given that quite efficient reinitiation still occurs in FCV and BM2 RNAs when the wild-type AUG is mutated to non-AUG codons [11], [15], [17], this observation suggests that when the wild-type +1 AUG has been mutated, there is a strong possibility of some reinitiation occurring at the -1 AUA codon.

For example, in strains of S. cerevisiae where multidrug resistant genes PDR1, PDR3, or PDR5 are mutated, there is increased sensitivity to mucidin, an MRC inhibitor [ 20].

Strikingly, when residues that mediate the V-shaped or KD KD interfaces are mutated, there is a complete loss of activation loop phosphorylation signal and consequently minimal activity toward IκBα.

When CDH1 is mutated, there is loss of normal cell adhesion and cell polarity; disaggregation of cells also promotes local invasion and metastases of neoplastic cells, and loss of CDH1 is a common molecular event in advanced sporadic malignancies [ 13- 16].

In zebrafish, ectopic Wnt11 (a Wnt-PCP pathway ligand) induces ectopic expression of Pax6 and the formation of bigger eyes, whereas, when mutated (silberblick mutation) there is a partial fusion of the eye field, possibly reflecting defects in morphogenetic movements (Cavodeassi et al., 2005; Heisenberg et al., 2000).

Notably, when KRAS codon 12-mutated tumours were compared with tumours being either KRAS wild-type or codon 13-mutated, there was a significantly higher proportion of mucinous tumours in the former category (p = 0.032 and p = 0.024).

The data presented here demonstrate that when all six residues are mutated simultaneously, there is a significant effect on cofactor activity.