Sentence examples for mutated such that from inspiring English sources

Our approach to assess the functional significance of S1 cleavage was to monitor the activity of Notch proteins that have been mutated such that cleavage is impaired.

A particularly striking example was when the anchor domain of Fyn was mutated such that it did not allow lipidic modifications of Fyn; the resulting protein was confined to the cytosol and did not transfer by trogocytosis any more.

It is possible that this strain derives its invasive potential from genes other than speA, or it is possible that the gene has mutated such that it yields a false negative result for speA by PCR but still retains functional expression of the SpeA protein.

These cells express β1-adrenoceptors that have been mutated such that the residues in TM4 are those of the β2-adroceptor (11).

When the SKU5 coding region is mutated such that no protein is produced, seedlings exhibit an enhanced skewing over the wild-type (Sedbrook et al. 2002).

The association of Nck-Pak1 is essential for TCR-mediated activation of NFAT transcription factor, since inhibition of NFAT transcriptional activity has been observed when the SH3.2 domain of Nck was mutated such that it failed to bind to Pak1.

A study of 25 breast cancers revealed diverse patterns of mutation, with a variation in the number of mutations and in the identity of mutated genes, such that no commonly point-mutated kinase gene was identified [10].

The cis portion of the complementation test essentially acts as a control and involves creating heterozygotes (one mutated chromosome and one wild-type, or normal, chromosome) such that one parent bears both mutations.

In studies of various melanoma cell lines having the most common c-kit mutations, HIF-1α was found to be essential for their proliferative potential, such that mutated melanoma cells proliferated only in hypoxic conditions or in the presence of overexpressed HIF-1α.

It was proposed that this property of the mutants might be the result of conformational differences transduced to the E ectodomain from the mutated TMD α-helix such that the epitopes of the mutants are presented to the host immune system in a more efficient manner or that new epitopes are exposed.

(5) Set of random mutations: We randomly selected one mutation in each of the 28,913 proteins from the set of mutants of unknown disease relation such that the mutated position was maximally distant from any other mutation observed in the given protein.