Sentence examples for mutated sequence from inspiring English sources
The phrase "mutated sequence" is correct and usable in written English
It can be used when describing a change or alteration in a sequence of something, such as a genetic or protein sequence. Example: The scientists discovered a mutated sequence in the DNA of the virus, which could explain its resistance to certain medication.
The shRNA non-targetable Beclin 1 constructs harbor silent mutations (mutated sequence: GGAAGCAAAACTAGTAACA) in the region of beclin 1 targeted by shRNA (GGGTCTAAGACGTCCAACA) (sense strand) in order to rescue the effects of knockdown of endogenous Beclin 1.
If the introduced mutations do increase cellular fitness, the mutated sequence is likely to be conserved and a tight regulation of the availability of such sequence will prevent undesired aggregation and keep functional aggregation under control.
For this last category, the allelic sequence identical to that of the human and bovine strains was considered to be the ancestral sequence, allowing to discriminate the mutated sequence and the nature of the mutation (insertion or deletion of nucleotides).
Plasmids that did not have the expected mutated sequence had the original sequence without a mutation.
Then, four DNA samples from the pool in which a mutation was detected were sequenced separately to determine the mutated sequence.
As long as the ratio between EGFR-mutated and normal cells was more than 1 3, the mutated sequence could be detected by the Sanger's sequencing method [32].
The mutant 3′-UTR of PLD1, which carried the mutated sequence in the complementary site for the seed region of miR-638, was constructed based on the p-Luc-PLD1 3′UTR-WT plasmid by overlap-extension PCR.
The mutant 3′UTRs of AMFR and NOTCH1, which carry the mutated sequence in the complementary site of the seed region of miR-139-5p miR-139-5p miR-139-5ptheir 3′UTR-werelasmids by overlap-extension PCR.
A transgenic line with biallelic mutations (a 1-nt deletion of the 17th "C" and a 4-nt deletion of the 14th "CATC", as shown in the first and the fourth mutated sequence in Figure 1b) was selected.
In experiments with mutated ACS, the mutated sequence (5' GCCGCGCGCCGCCGGCG) replaced the targeted ACS motif.
A mutated sequence (DAEFAHDSGAEVHHQELVFFAEDVG) and a scrambled sequence (FYHDESEFGHAVEQFGRDVEAVHDL) were also coupled to the fluorophores and to myc as controls.
