Sentence examples for mutated on the from inspiring English sources

Two family GH-18 chitinases mutated on the key catalytic amino acids were evaluated as "glycosynthases" for the coupling of oxazoline activated donor to chitin oligosaccharide (COs) acceptors obtained from microbial fermentation.

Walking on Robinson, looking for delicate endemic ferns at the blackberry's margins, I began to see the novel as an organism that had mutated, on the island of England, into a virulent invasive that then spread from country to country until it conquered the planet.

Bacillus circulans WL-12 chitinase A1 (Bc ChiA1) and Trichoderma harzanium chitinase 42 (Th Chit42) were individually mutated on the three conserved carboxylic acids, all suggested to have a role in catalysis: the general acid/base glutamate and the two aspartates, defined as the putative stabilizer and its assistant.

The residues L40, A113, V291, and V294, in leucine dehydrogenase (LeuDH), predicted to be involved in recognition of the substrate side chain, have been mutated on the basis of the molecular modeling to mimic the substrate specificities of phenylalanine (PheDH), glutamate (GluDH), and lysine dehydrogenases (LysDH).

The patient-derived monoclonal antibody 6_2G3 bound to 2 out of 6 of the melanoma cell lines evaluated compared to melanocytes, suggesting that this antibody may be against a protein over-expressed or mutated on the surface of cancer cells.

Such degradation did not occur when MDM2 was overexpressed in HCT116 that also overexpressed an HIF1 α mutated on the three residues responsible for hydroxylation-dependent degradation, suggesting these residues to be essential.

Indeed when Pmp23 is absent or is mutated on one of the putative catalytic residues E61 or D68, S. pneumoniae cells are larger and longer, and a portion of them displays severe morphological and division defects.

Mutations are very rare events—a given base in the genome has a probability of mutating on the order of 10− to 10− per generation and direct detection of mutations de novo has historically involved extrapolation from a small set of detectable mutations whose properties may not be representative of the genome as a whole (Drake et al. 1998; Sniegowski et al. 2000; Baer et al. 2007; Lynch 2010).

Semi-rational approaches that target multiple, specific residues to mutate on the basis of prior structural or functional knowledge create 'smart' libraries that are more likely to yield positive results.

The nerve endings of elementary school aged children actually mutate on the last day of 6th grade; and, their skin no longer feels the elements of cold and wind.

This hypothesis is strengthened by data on receptor Gα fusions; receptor stability and the extent of dimerization differs according to whether Gα is fused to the receptor mutated on TM IV or to the one on TM V (Fig 5B).