Sentence examples for mutated myosin of from inspiring English sources

As previously published, the British patient with V606M had 12 ± 6% and the patient with mutation G584R had 23±1%1% mutated myosin of total β-MHC, respectively [ 26].

Preliminary β-MHC quantification of cardiac samples from patient H27 yielded essentially the same fraction of 62.7 ± 11% (n = 2 peptide samples) mutated myosin of total myosin as found in M. soleus.

β-MHC quantifications in M. soleus biopsies (Table  1) of two patients with mutation R723G (H27 and H28) yielded 61.6 ± 6% (n = 36 peptide samples) and 62.4 ± 7% (n = 31 peptide samples) mutated myosin of total β-MHC, respectively [ 5].

The siblings with mutation I736T had 43 ± 13, 33 ± 3 and 42 ± 7% (n = 4 7 muscle samples) mutated myosin of total β-MHC in the sarcomeres of their M. soleus, respectively.

The American patient with mutation V606M had 13 ± 2% (n = 3 peptide samples of 1 muscle sample) mutated myosin of total β-MHC.

The aberrant accumulations of myosin in the muscle fibers of affected individuals with myosin storage myopathy might be due to improper incorporation of mutated myosin into thick filaments or disassembly of the filaments resulting in accumulation of mutant protein between the myofibrils and beneath the sarcolemma.

The fraction of mutated myosin in the soleus muscle biopsy of the patient with mutation R719W was 54 ± 7% (n = 4 muscle samples).

Both mutations, R723G and R719W, also caused a pronounced increase in resistance to elastic deformation and substantial increase in force generation of the mutated myosin heads [ 15, 17, 36].

This raised several questions: (1) Is the deviation from the expected 50-to-50 50-to-50 50-to-50e veratiomutated myofin at the protein level paralleled by similar changes at the mRNA level due to allelic imbalance?

The main source of mutated cardiac myosin is from transgenic mice, but they express primarily α-cardiac myosin in the ventricles throughout adult life.

The fraction of wild-type and mutated β-myosin was determined after myosin extraction and enzymatic cleavage using liquid chromatography/electrospray-ionization mass-spectrometry (LC/ESI-MS) or LC/MS in combination with capillary zone electrophoresis, which we previously developed [ 5, 26].