Sentence examples for mutated in this from inspiring English sources

ATM (A-T, mutated) is the sole gene mutated in this disease and encodes a Ser/Thr protein kinase that belongs to the phosphatidylinositol 3-kinase (PI3K) superfamily.

The gene mutated in this disease, ATM (A-T, mutated), encodes a 370-kDa Ser/Thr protein kinase.

To understand the unusual specificity of the scpt mutation, we sought to identify the gene(s) mutated in this stock.

The high fraction of the genome mutated in this SP allowed for its detection even at low mutation count.

Moreover, we assessed the co-existence of mutations in MLK3 and in KRAS and BRAF genes, which are frequently mutated in this type of neoplasia.

It is tempting to speculate that MAPK activation in uveal melanoma may arise via crosstalk with the PI3K/PTEN/AKT pathway, possibly as a consequence of mutation of some of its components (other than PTEN, which is not mutated in this tumour type).

They then compared the healthy and tumorous genomes of each patient, in order to discover which genes had mutated in the cancer.In this, they were following the normal protocol of the cancer genome consortium.

The development of genetic tests for this syndrome has identified WFS1 as the main locus mutated in the majority of this patient population [ 9].

Errors in crossover are especially likely when similar sequences cause partner chromosomes to adopt a mistaken alignment; this makes some regions in genomes more prone to mutating in this way.

When mutated in humans, this results in primary microcephaly, which is manifested by a greatly reduced brain size [ 6].

Provided that the physiologically occurring molecule EBAG9 is indeed dysregulated or mutated in tumors, this should prompt further investigations on the role of EBAG9 in the modulation of O-linked glycan expression.