Sentence examples for mutated in their from inspiring English sources

Patients whose carcinomas had at least three of these driver genes mutated showed a worse prognosis than those patients who had only one or two of these genes mutated in their carcinoma; patients whose carcinomas harbored at least three mutated genes also had high metastatic burden at autopsy.

In directed evolution experiments, additional compensating mutations were required to restore wild-type levels of activity to proteases mutated in their specificity pockets (Varadarajan et al., 2008).

Alfalfa mosaic virus RNA3 leader sequences mutated in their base complementarity to the viral template, or the nucleotides 5′ of potential base-pairing residues, were tested for their use either singly or in competition.

Also under these conditions, the ATPase activity could be attributed to cohesin because a cohesin trimer in which both Smc1 and Smc3 had been mutated in their Walker B motifs (EQ) showed much less ATP hydrolysis activity.

The gyrA and parC genes were mutated in their quinolone resistance determining region in all isolates of the MDR clone CG258, whereas no mutation of these genes was found among the hypervirulent clones.

To confirm that RIP3-KD activated the caspase-dependent cleavage of p65/RelA and to analyze the specificity of the smaller band observed with the C22B4 mAb, we generated five p65/RelA constructs that were mutated in their caspase-3 or -6 consensus recognition sites and contained His-tags in their C-terminus.

We applied the NetHiKe algorithm to the list of genes that are somatically mutated in glioblastomas using their observed mutation frequencies as the weight values.

They also encode genes such as MCC (mutated in colorectal cancer) with their role in CRC etiology unknown.

Oncogenes tend to be recurrently mutated at the same amino acid positions, whereas tumor suppressor genes are generally mutated in various positions throughout their length.

The main focus of this paper was to identify the number of tumor suppressor genes differentially methylated in the greater promoter region and mutated in HNSCC, and examine their combined impact in expression downregulation.

Mutated NarQ proteins were expressed in E. coli strains mutated in narX and narQ and their ability to activate nirB:: lacZ or repress frdA:: lacZ chromosomal fusions was assessed using β-galactosidase assays (Table 3).