Sentence examples for mutated in silico from inspiring English sources

For the lysine mutations, for the sake of representation, the corresponding residue in paddle chimera was mutated in silico (in Coot) to lysine, and the rotamer of lysine with the least distance between the corresponding toxin residue was chosen.

To test whether there is selection pressure on the cells to be speed-independent, the speed-independent models for both budding yeast and fission yeast were mutated in silico.

Starting from the third residue, the sequence was systematically mutated in silico to increase the number of tryptophan residues.

In the next step the optimized native structure was mutated in silico, and mutant structures were optimized in the same way.

Namely, the coordinates of the Cys249Ser PaDDAH/ l-citrulline complex crystal structure (PDB code 1H70) were mutated in silico to include the substitutions Arg40Glu, Arg98His, and Cys249Ser.

To optimize identification of novel subtypes, we developed an amino acid substitution database in which every amino acid within the BoNT/B1 Okra sequence was mutated in silico to 19 other possibilities.

Each sequence grouping was mutated in-silico with custom scripts used to introduce a combination of 20 SNPs and 13 INDELs from a test set of 2211 12999 unique) known BRCA1 variants containing 1340 SNPs, 320 insertions and 551 deletions.

To compare the metal-binding strength, we mutated Met in silico to CysH/Cys− and performed the calculations.

In silico, 217 kinases were identified to be mutated in cancer and 76 have been reported to contain non-synonymous somatic mutations in at least two independent tumor samples in the literature.

Class 1 PI3Ks are mutated in many cancers.

The residues mutated in this work are labeled in red.