Sentence examples for mutated in prostate from inspiring English sources

These studies confirmed that the most commonly mutated gene was AR, however no single gene other than AR had frequent mutations and even common, broadly mutated oncogenes such as PIK3CA, KRAS, and BRAF are not commonly mutated in prostate cancer [ 9].

Usually, phosphatase and tensin homologue that has been deleted on chromosome 10 is mutated in prostate cancer.

Genes believed to modulate AR activity and that are mutated in prostate cancer include the nuclear receptor co-activator 2 gene (NCOA2) and forkhead-box A1 (FOXA1).

To identify potential tumor-suppressor genes mutated in prostate cancer cell lines, we applied a version of GINI that involves inhibition of NMD in two steps.

Transcriptional targets of MYC include many genes that were identified as conferring risk of prostate cancer and/or being somatically mutated in prostate tumors [ 28, 29].

Although Ras is infrequently mutated in prostate cancer, overexpression of wild-type Ras can be sufficient to induce malignant transformation in human prostate epithelial cells (Weber and Gioeli 2004).

The SPOP E3 ubiquitin ligase gene is frequently mutated in human prostate cancers.

Frequently, the AR is mutated in advanced prostate cancers, which results in a receptor that can be activated by nonandrogens (Culig et al. 2001).

The RB1 gene is more commonly deleted or mutated in castration-resistant prostate cancer (up to 45% of patients) than in clinically localised prostate cancer, and is coincident with the emergence of castrate-resistant disease (Taylor et al, 2010; Grasso et al, 2012).

Among them, PTEN is frequently mutated in thyroid and prostate malignancies.

In addition to endometrial cancer, PTEN is frequently mutated in brain and prostate cancer (Cairns et al, 1997; Li and Sun, 1998).