Sentence examples for mutated in more from inspiring English sources

The HPR NSCLCs had much more mutations, e.g., the total number of mutated genes (Fig. 2A), recurrent mutated genes (Fig. 2B), and genes mutated in more than 3%10%% tumor samples (Fig. 2C, Table 2), than the CR patients.

We present an innovative course-based undergraduate research experience curriculum focused on the characterization of single point mutations in p53, a tumor suppressor gene that is mutated in more than 50% of human cancers.

The first NGS studies of breast cancer (BC) identified only three genes mutated in more than 10%% of BC tumors: TP53 (mutation rate 40%% of tumors), PI3K (25%% of tumors), and GATA3 (10%% of tumors).

For all genes mutated in more than five samples, intron retention was analyzed in the mutated sample set compared to all wild-type tumor samples.

Twenty-eight genes (∼64%) were mutated in more than one cytogenetic subgroup, covering 383 of the 416 mutations identified in all samples (∼92%).

BRAF is mutated in more than 50% of all melanomas, with BRAFV600E being the predominant mutation, increasing the protein's kinase activity and, thereby, driving downstream cellular proliferation through the MAPK pathway [4].

Furthermore, highly ranked weak spots that are also highly conserved with respect to the amino acid type found at that sequence position are nevertheless found to be mutated in the more stable CS.

To date, no individual gene has been found to be mutated in a more than a small percentage of NTD patients, supporting the idea of wide genetic heterogeneity.

For the time being, their recurrence rate within and between cancer types serves as a proxy for this status; that is, genes mutated in cancer more often than expected by chance are considered to be drivers.

We then applied MutSig (Lawrence et al., 2013) on 5173 somatic SNVs assigned to 136 SPD from 69 primary GBM patients whereby we identified genes that were mutated in SPD more often than expected by chance.

In contrast, the disease-causing nsSNPs tend to be concentrated at structurally equivalent positions, with a significant excess of mutations occurring at positions mutated in four or more different protein kinases.