Sentence examples for mutated in lung from inspiring English sources
Mutations in the RAS gene, a gene frequently mutated in lung cancer, were not prognostic [ 2], however they largely influenced accuracy of transcription-based biomarkers for non-small cell lung cancer.
The adipocytokine signalling pathway also contains a significant number of genes that are mutated in lung and colorectal cancers (19 and 14 mutated genes, respectively; Q-value <0.01; Fig 1; Table 2).
The p53 gene is reported to be frequently mutated in lung SQCs (Sanchez-Cespedes, 2003), and missense mutations frequently cause the abnormal accumulation of p53 (Toyooka et al, 2003).
As many genes are mutated in lung carcinomas (K-Ras, EGFR for example), mutational analysis of RhoB sequence has been performed by several teams in various tumors [ 3, 15, 17] and were all negative.
Taking the overall mutation rate of c-CBL to be a combination as somatic missense mutation and LOH, it is clear that c-CBL is highly mutated in lung cancers and may play an essential role in lung tumorigenesis and metastasis.
This brings the total number of invasive epithelial ovarian cancer cases reported to 305 with a mutation rate of 0.7%% when only the exons known to be mutated in lung cancer are considered.
We report here a thorough study to address the physiological role of the putative lung cancer tumor suppressor EPH receptor A3 (EPHa3), a gene that is frequently mutated in human lung adenocarcinomas.
For instance, the mammalian target of rapamycin mTor signalling pathway contains a significant number of genes that are mutated in brain, lung, melanoma, colorectal and ovarian cancers, but only 48% of the mutated genes are shared among these tumour types.
The results suggested that the hMAD2 gene is not commonly mutated in either lung nor breast cancers.
Fig. 3 a 100 specific loci ("hotspots") frequently mutated in the lung adenocarcinoma dataset (n = 519) ranked based on shared coverage across the dataset.
While KRAS is commonly mutated in human lung adenocarcinomas (~21%), it is rarely altered in SCC (~6%) (Perez-Moreno et al., 2012).
