Sentence examples for mutated in its from inspiring English sources

We defined a candidate cancer gene as recessive when affected by mutations potentially leading to loss of function; i.e. when it was frequently mutated in its coding region and frequently altered in its genomic structure, in particular deleted.

In their absence, or if the protein is truncated or mutated in its C-terminal region, the enzyme is uncoupled or it fails to assemble [ 34].

CL4-displaying BV interacted with a CL4 binder, the C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE), but it did not interact with C-CPE that was mutated in its CL4-binding region.

To assess the structural requirements of Mdm2 to regulate FOXO4 transcriptional activity we compared the effect of wild-type Mdm2 on FOXO4 transcriptional activity with that of Mdm2 mutated in its RING domain, and with that of Mdm2 mutated in its p53 interaction domain (Fig. 3c).

However, upon treatment with known proteasome inhibitors (e.g. MG132, Bortezomib and ALLN), PIR translocates into the nucleus in a manner reminiscent of p53 mutated in its NLS (Fig. 1B upper panel) [31].

In hereditary non-polyposis colon cancer (HNPCC), APC is wild type but β-catenin is mutated in its N-terminal phosphorylation sites.

In contrast to other cancers RB1 is rarely mutated in mesothelioma but its suppressor function is inhibited due to inactivation by phosphorylation or by viruses as SV40[23] that recently was linked to mesothelioma oncogenesis.

Although p73 is not commonly mutated in human cancer, its function as tumour suppressor has been largely documented.

We examined four alleles that were reported to differentially affect the Mrc1 role in checkpoint activation: the mrc1-aq allele is mutated in all of its phosphorylation sites and is incapable of mediating the checkpoint signal [ 36].

Here we describe such a model, using C. elegans containing loss of function mutations in dnj-14 (the worm orthologue of the DNAJC5 gene mutated in ANCL); and demonstrate its potential for chemical genetic screening, by identifying a sir-2.1-independent neuroprotective effect of resveratrol.

The gene encoding p16/CDKN2A is neither deleted nor mutated in pituitary tumors; however, its associated CpG island is frequently methylated and is associated with a loss of p16 protein expression.