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Exact(5)
Point mutations in exons 1 and 2 were always found in cases mutated in either exon 9 or exon 20, but the two tumors with deletions did not present any additional PIK3CA mutations in other exons.
The results suggested that the hMAD2 gene is not commonly mutated in either lung nor breast cancers.
We used different ubiquitin constructs mutated in either Lys48 (K48R) or Lys63 (K63R), unable to oligomerize at those residues.
To our knowledge, our list of CP genes (Table 2) covers the most comprehensive number of genes (n = 322), which cause CP when mutated in either species alone or both species [ 39, 40].
This dataset reveals 20 genes that are specifically mutated in either p19 ARF-deficient, p53-deficient or wild-type mice (including Flt3, mmu-mir-106a-363, Smg6, and Ccnd3), as well as networks of significant collaborative and mutually exclusive interactions between cancer genes.
Similar(55)
Where the appearance of health detriment is delayed by months to years, as in the case of cancer, it was assumed that specific genes became mutated in ways that either promoted inappropriate growth of cells in the affected tissue or failed to suppress such growth.
It cannot be attributed to differences in amino-acid sequence, because α-synuclein is not typically mutated in the common form of either condition4,5.
The three S/TP sites found at the p57 N-term fragment were then mutated in full-length p57 to either glycine or alanine and assayed in vitro.
More than half of the fork mutations affected positions that were also mutated in termination-altering variants of either the E. coli β or yeast Ret1 subunit.
Thirty-nine of the 41 genes mutated either in our study or in the TCGA dataset were mutated in the same fraction of samples (P ≥0.05; Figure 3).
Components of the spliceosome are frequently mutated in haematopoietic malignancies.
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