Sentence examples for mutated in both from inspiring English sources

Critically, no significant differences were observed in the mutation rates of many other genes frequently mutated in both cohorts (CASP8, CDH10, EP300, FAT1, MLL2/ KMLL3/ MLL3/ KMT2C, NSD1, PIK3CA, PLEC, SYNE1, and USH2A).

We used assays with spatiotemporal resolution in Drosophila melanogaster (fruit fly) and Danio rerio (zebrafish) to quantify signaling changes caused by mutations in MAP2K1 (encoding MEK), a core component of the Ras pathway that is mutated in both RASopathies and cancers in humans.

Further tests conclusively showed that the BRCA2 gene was mutated in both.

Among them, 1383 genes were mutated in both strains, while 774 genes were mutated only in GXG-5, which much more than that of 360 genes in GXA-28 (Additional file 1: Figure S3).

Multiorgan autoimmune disorders result when this population is removed in normal mice and when FoxP3 is mutated in both humans and mice [10].

Within our high priority genes, encompassing all genes which pass all selection filters, BMPR1A stands out as mutated in both cases.

Similarly, deficiency of most other RPs that are mutated in DBA, both from the small and the large ribosomal subunits, affects pre-rRNA processing in a unique way, leading to the accumulation of different rRNA precursors and disruption of ribosome biogenesis at different steps (Robledo et al., 2008).

The great majority of skin tumours are mutated in one or both Trp 53 alleles, suggesting that p53 function may influence the increased cancer risk.

The role of mitophagy in Parkinson's disease has been an area of interest following observations that the protein kinase PINK1 and E3 ubiquitin ligase Parkin, both mutated in early onset forms of Parkinson's disease, act to induce mitophagy on mitochondrial membrane depolarization [ 7].

To validate antibody specificity, epitope-tagged cortactin constructs containing wild-type (WT) cortactin, cortactin with individual serine to alanine mutations at codon 405 (S405A), codon 418 (S418A) or with both codons mutated in tandem (S405,418A) were produced and transfected into 1483 cells.

To our knowledge, our list of CP genes (Table  2) covers the most comprehensive number of genes (n = 322), which cause CP when mutated in either species alone or both species [ 39, 40].