Sentence examples for mutated compared with from inspiring English sources

In this study, we found that almost all BRCA1-mutated tumors and BLBCs are TP53 mutated compared with 25-50% of the luminal-tumors.

Based on a functional TP53 expression assay in yeast 57% of 63 IBC samples were mutated, compared with 37% of 27 non-inflammatory LABC samples [ 17].

In agreement with our results from the in vivo complementation assays, the protein level of MIA substrates (small Tim proteins and Erv1), which are essential for cell growth, was significantly decreased in mitochondria containing Erv1 with either one or both of the N-terminal shuttle cysteine residues mutated compared with that of the WT.

These results confirm that the outcome of HER2-positive patients treated with trastuzumab is significantly worse in patients with PIK3CA-mutated compared with wild-type tumours.

When BC was classified into different molecular classes based on BRCA1 and ER status, high KPNA2 expression was identified in BRCA1-negative/ER-negative phenotype and in BRCA1-mutated compared with BRCA1-positive/ER-positive classes (P<0.0001; Figure 4).

We did not observe a greater beneficial effect of platinum-based HD-PB chemotherapy over conventional chemotherapy in BRCA1-mutated compared with non- BRCA1-mutated breast cancers in the context of a RCT, which might at least partly be caused by the small numbers.

Then the researchers found that in brain cancer cells in the lab, enzymes that typically produce energy were virtually inactive in mutated cells compared with normal IDH cells--suggesting that these cells aren't metabolizing energy as efficiently and have less to grow on.

Survival tended to be longer in patients with mutated EGFR compared with those with wild-type EGFR (HR 0.61; P=0.61).

None of the sequences showed an overrepresentation of the mutated allele compared with the wild-type allele.

Given the favorable TTF and OS in the gefitinib group, gefitinib was just as effective in the elderly with mutated EGFR compared with their younger counterparts.

In the studies from Buttitta [ 6] and Barbareschi [ 8], patients with lobular breast cancer had more often PIK3CA exon 9 mutated tumors compared with nonlobular breast cancer.