Sentence examples for mutated and unmutated from inspiring English sources
Recent studies have demonstrated substantial differences in genomic alterations between mutated and unmutated IGHV subgroups, which reflect distinct molecular pathways and mutagenic mechanisms in the pathogenesis of the disease.
Numerous genes were suggested based on gene expression profiles comparing IgVH mutated and unmutated patients [7], [8].
We analysed ROC curves with GraphPad Prism 5.0 Graph-Pad Softwaree) to determine the ZAP70, LPL, CLLU1, miR-29c, miR-223, CD38, sCD23 and β2-M expression cut-off values that best distinguished mutated and unmutated cases.
In a next step we evaluated whether differences between JAK2 mutated and unmutated MPN cases with fibrosis could be established.
For this reason, we believe that it could be involved in both mutated and unmutated CLL subsets.
The signal for the deaminases is found at similar frequency within both mutated and unmutated promoters and at unmutated intergenic regions.
These findings suggest that although the CpGs that undergo methylation changes during progression overlap those that change during the development from naive to memory cells, or transition from naive to CLL, they are not the same as those that differ between IGHV-mutated and unmutated CLL or those that are change during the transition from memory cells to CLL.
The survival data were grouped into mutated (26 patients) and unmutated (30 patients) cases and a statistically significant difference in overall survival was found between these two groups (P<0.001).
One of the strongest prognostic markers for CLL is the mutational status of the immunoglobulin variable (IgV) heavy chain at the rearranged VDJ region constituting the BCR, dividing the disease into IgV-mutated (IgV-Mut) and unmutated (IgV-UM) CLL, with IgV-UM having the worse prognosis [2], [3].
It defines two different subsets of CLL based on the cutoff value of 98% identity with the closest germ line IGHV genes: mutated CLL (M-CLL) and unmutated CLL (U-CLL).
Using this method, methylation profiles have been shown to vary substantially between CLL with mutated versus unmutated IGHV status and to mirror epigenetic differences seen between naive and memory B cells.
