Sentence examples for mutated and a from inspiring English sources
Studies performing large-scale conventional sequencing of breast cancers [ 33, 34] revealed that there are a relatively low number of genes frequently mutated and a high number of genes rarely mutated in breast cancer.
The cells were transiently cotransfected with ADAR2 or a mutant where either single or both PPxY motifs in ADAR2 were mutated and a further construct expressing WWP2.
We observed significant inhibition of promoter activity when either site was mutated and a synergistic effect when both sites were mutated (Fig 8H).
Patients with mutations only detected by shearwater generally display the expected behavior that is on average better survival if SF3B1 was mutated, poor survival if TP53 or STAG2 were mutated and a moderate change for DNMT3A.
Iteratively, this oligonucleotide was randomly mutated and a score was computed as m/(m t * (1 + t + r)), where m, t, and r are the number of hits of the degenerate sequence to the annotated mRNAs, tRNAs, and rRNAs, respectively, and m t is the total number of annotated mRNAs.
In addition, a double mutant was created where the most conserved sites 137C and 137D were changed simultaneously, a triple mutant with 137B, 137C and 137D mutated and a mutant where all four potential binding sites were changed (Fig. 1C).
In other cases a gene has undergone duplication and one copy has mutated and become a pseudogene.
This suggests that the spacer sequence, but not trcF, was mutated and has a relatively low impact on the host.
These signatures depend on the functional domain mutated and, for a specific subgroup, are shared with BLBC patients.
During evolution, this gene in T. urartu was mutated and became a pseudo-gene, but the gene in Ae. tauschii and common wheat maintained an intact ORF.
Way up where a celestial blue is nearly all you can see, where atmospheres begin to merge and mutate and an unblinking, unceasing, total and utter darkness edges into view, fifteen seconds becomes something malleable.
