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If it is able to circulate for some considerable time, it can mutate to a strain capable of causing disease, called a circulating vaccine-derived poliovirus.
"We're attempting to stamp out this strain before it has a chance to mutate to a highly pathogenic strain, which still would not necessarily cause a human illness".
Under direction by moderator Sharon Begley, the senior U.S. Health and Science correspondent for Reuters, the panelists agreed that the creation in laboratories of a different form of H5N1, one that could now pass from mammal to mammal, was done with the best intentions: to determine whether this virus could mutate to a form that is more deadly to humans.
Now an outbreak on the island of Hispaniola demonstrates that the vaccine can mutate to a virulent form and spread.
For example, regulatory binding sites may mutate to a state for which there is not currently a matching gene product being produced.
Reciprocally, the number of S allele loci that mutate to a P allele and become fixed is NpdµΨ.
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The number of P allele loci that mutate to an S allele and become fixed is N(1 − p) cµΨ.
In the set of the evolutionarily conserved mutations, we isolated the P1 mutant, in which a conserved tyrosine residue is mutated to a histidine residue.
But in nine months it mutated to a highly virulent one.
Therefore, a CG base pair will have mutated to a TA base pair.
On protecting America against terrorists, their nine-point advantage has mutated to a seven-point deficit.
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