Sentence examples for mutate at the from inspiring English sources

They found that these regulatory sequences had acquired fewer mutations than had sequences thought to mutate at the genome's baseline rate.

This averaging destroys information on correlated mutations, where two positions in the polypeptide chain mutate at the same time.

We first demonstrated that in two distinct lineages, LTR-retrotransposons mutate at the same rate.

The original reason to mutate at the chosen positions was their high B-factor, which suggests that it is a critical spot in the protein.

Interestingly, in the case of TAA-52, one revertant sequence bears a point mutation to TAC, thus mutated at the third A∶T base pair, instead of the expected reversion to AAA or wild-type AAG (Table 1).

TP53 is mutated at the end of the mutation pathway, and many cancer cells without a mutation in this gene can be observed within the specimen [ 22- 25].

Presumably, when an oncogene is recurrently mutated at the same amino acid position, this signifies a driver mutation, and driver mutations in tumor suppressor genes are those that cause protein truncation alterations 6.

To test presence of the R46X transcript mutation in leukemic cell lines derived from PBMCs, we amplified SDHB cDNAs mutated at the TaqI RE site by RT-ePCR.

In their study, the HA gene was mutated at the nucleotide level, so their experiments surveyed only amino-acid mutations accessible by single-nucleotide codon changes.

The first (IP3RL60E) is mutated at the 8-position of the 1-8-14 1-8-14 1-8-14 second has motifions andbothethe 1- (F53E) and 14-poseconds (Y66E) (IP3RFY).

To express wild-type Sp1 protein from mRNA resistant to pSuper-Sp1, the human Sp1 cDNA coding sequence was silently mutated at the target sequence to 5′-GAAT AG AACA GTC AGTGGT-3′ (mutations underlined), and cloned into the pCMV-3Tag-1 vector.