Sentence examples for mutants without any from inspiring English sources

When inhibition was considered (n = 1), the increase in superoxide was further attenuated, such that superoxide levels, even in complete knockout mutants without any other (for instance genetic) compensation, at most rose approximately 3 fold (Figure 8 bottom).

70, 71 On the other hand, Prenen and colleagues reported a series of 200 patients with 12% PI3K mutants without any correlation of PI3K mutations to cetuximab response.

However, this conclusion is based exclusively on experiments with phosphorylation-mimicking mutants, without any comparison with the corresponding non-phosphorylatable counterparts.

Consequently, this automated analysis enables us to screen numerous mutants simultaneously and to rapidly select for early-granuloma-deficient mutants without any bias.

This is a simple and efficient method for targeted gene disruption and allows generation of homozygous null mutants without any crossing, and these mutants can be maintained unchanged for generations.

Although LexA has been suggested to have nuclear-localization properties [ 88], Dot1 mutants without an N-terminal domain were fused to an NLS.

The likely consequence of such rapid selection of resistant mutants without an efficient method to remove them from the population, is escalating macrolide resistance in high-risk populations.

Arabidopsis mutants without a functioning SQD2 protein showed retarded growth under P deficiency supporting the importance of sulfolipid in the adaptation response [ 85].

Previous studies have shown that Fmi levels at apical junctions are slightly increased in dsh mutants [21], without any corresponding change in Fz levels [22].

In conclusion, pHJOFpac is an ideal construct for the rapid production of VZV mutants without the retention of any unwanted operational sequences in the manipulated viral genome.

As described above, the most fundamental pathological change was the age- and expanded-polyQ-length-dependent NIA of mutant proteins without any obvious neuronal loss, raising the possibility that such an NIA of mutant proteins leads to neuronal dysfunction including synaptic transmissions through transcriptional dysregulations.